Libby Lane, born in 1966, is saxophone player with a taste for football who was appointed in December as the new bishop of Stockport, a town outside Manchester in northwest England.
Her nomination came a month after England's state church gave final approval to the dramatic change to its hierarchy following years of wrangling and division.
The move was hailed as an important step towards greater equality.
She was consecrated in York Minster on January 26 but Sunday's ceremony in Chester, northwest England, marks the formal beginning of her ministry in her diocese.
She will be presented with her pastoral staff and be welcomed by the civic and faith communities in a service expected to be attended by more than 1,500 people.
As bishop of Stockport, Lane is a suffragan (assistant) bishop in the Diocese of Chester.
Gordon McPhate, the dean of Chester, said: "We are honoured to welcome the bishop of Stockport and her supporters to this installation service at the cathedral.
"The service will mark a day of worship and celebration — for men and women alike — as a new chapter is created in the Church of England."
The church's move ended a tortuous process allowing for female bishops that set liberal and conservative believers at odds.
The Church of England backed the introduction of female priests in 1992 and the first were appointed two years later.
They now make up one-third of the clergy.
The Church of England separated from the Roman Catholic Church in 1534. It claims that more than 40 percent of people in England regard themselves as belonging to the Church of England.
It is the mother church of the global Anglican Communion, which has around 85 million followers in more than 165 countries.
Other Anglican churches around the world have been appointing female bishops for years.
The first was appointed in the United States in 1989 and there are now more than 30 worldwide, in countries such as Australia, Canada, Cuba, New Zealand and Swaziland.
Lane was educated at the University of Oxford and became a priest in 1994.
Her interests include learning to play the saxophone, supporting Manchester United Football Club, reading and doing cryptic crosswords.
Her husband, George, is also a minister. They were one of the first married couples in the church to be ordained together. He is a chaplain at Manchester Airport