The 19-year-old picked up the injury while going in for a tackle with an unnoticed teammate.
The on loan Juventus striker at Italian Serie-B club Sassuolo limped off the pitch with the unspecified injury.
The Black Stars medical team will assess his condition later in the evening and if necessary, will take him to the hospital tomorrow morning for further examination.
The injury to Boakye-Yiadom compounds the fitness situation in the Ghana camp ahead of the 2013 Africa Cup of Nations which commences this weekend.
Ghana is already sweating on the fitness of defender Isaac Vorsah and midfielder Anthony Annan who are battling minor injuries.
Coach Akwasi Appiah will be hoping to have all his players fit for Ghana's opening game against DR Congo on Sunday.
The team is expected to travel to South Africa on Wednesday – four clear days towards their opening Group B encounter.
The Black Stars who will be based in Port Elizabeth will also face Mali and Niger at the group stage.